<p>Description The Horowitz Laboratory is seeking a highly motivated postdoc to lead projects focused on basic and translational immunology. This opportunity is designed to study crosstalk between immune cells, stroma and tumors within tumor microenvironments in patients with cancer or autoimmunity. The candidate will actively participate in research studies that focus on evaluating the immune response in cohorts of patients treated with immunotherapy. Specifically, the candidate will be expected to manipulate solid tissues suitable for preparation to perform an array of experimental modalities, including but not limited to mass cytometry (CyTOF), single-cell RNA sequencing, spatial sequencing, multiplexed imaging, as well as in vitro and/or in vivo functional assays to assess immune responses in PBMCs/TILs from cancer patients. Additionally, the candidate will develop sequencing-based methodologies for sequencing HLA class I and class II and KIR genes. The responsibilities in this research include developing new immune assay approaches, improve the collection of clinical samples from cancer or precancerous patients through collaboration with clinicians (i.e. Urologic Oncologists), assist in interpreting moderately complex results, assist in the collection, analysis and review of experimental data for publication and presentation, and participate in laboratory meetings to present the progress of your research. She/He/They is expected to assist in scientific writing, developing novel research techniques and mentoring of Associate Researchers and Graduate trainees. A strong knowledge of NK cell, T cell, and myeloid cell immunology, Tumor immunology and experience with experimental methods to measure immune responses (T cell proliferation, ELISPOT, Tetramers, killing assays) is desirable. Applicants are required to have strong backgrounds in computational immunology and expertise in programming languages (e.g., R, Python). Most importantly, applicants are expected to maintain exceptional communication with the principal investigator. They are expected to present weekly progress at lab meetings as well. Responsibilities Essential Job Functions (including but not limited to): Conduct and design experiments under the direction of the lab PI. Conduct a variety of research experiments using advanced research techniques specific to subject matter of the research project (i.e. performing basic molecular and cellular biology methods including tissue culture as well as biochemistry techniques such as cytotoxicity assays, PCR, Western Blot and analysis of samples through flow cytometry, CyTOF, scRNA sequencing, etc). Must be able to read and understand scientific data being applied to conduct the research. Coordinates project activities to meet deadlines. Collaborates with the Principal Investigators in the development of new experiments and research techniques. Incumbents are expected to stay apprised of the literature as well as practical skill sets relevant to the field. Assists in the implementation of standardized protocols for experiments and training purposes; create and maintain Standard Operating Procedures (SOPs) specific for each study. Assists the Principal Investigator with publications by extracting and compiling moderate to complex research data (i.e. related to oncology, immunology, microbiology, etc); assisting in interpreting the data; reviewing and editing articles used in scientific publication. Must have strong science background. Mentors and trains less experienced research staff and graduate students in research techniques and use of equipment. Ensures compliance with safety and regulatory requirements. Performs other related duties. Qualifications Qualifications: Ph.D. required Experience working in a research laboratory setting The candidate is also expected to be highly self-motivated, creative and capable of contributing productively in a team environment. This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW. Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW-_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf. Employer Description Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai's unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.</p> <p>Qualifications: Ph.D. required Experience working in a research laboratory setting The candidate is also expected to be highly self-motivated, creative and capable of contributing productively in a team environment. This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW. Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW-_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf.</p> <p>Essential Job Functions (including but not limited to): Conduct and design experiments under the direction of the lab PI. Conduct a variety of research experiments using advanced research techniques specific to subject matter of the research project (i.e. performing basic molecular and cellular biology methods including tissue culture as well as biochemistry techniques such as cytotoxicity assays, PCR, Western Blot and analysis of samples through flow cytometry, CyTOF, scRNA sequencing, etc). Must be able to read and understand scientific data being applied to conduct the research. Coordinates project activities to meet deadlines. Collaborates with the Principal Investigators in the development of new experiments and research techniques. Incumbents are expected to stay apprised of the literature as well as practical skill sets relevant to the field. Assists in the implementation of standardized protocols for experiments and training purposes; create and maintain Standard Operating Procedures (SOPs) specific for each study. Assists the Principal Investigator with publications by extracting and compiling moderate to complex research data (i.e. related to oncology, immunology, microbiology, etc); assisting in interpreting the data; reviewing and editing articles used in scientific publication. Must have strong science background. Mentors and trains less experienced research staff and graduate students in research techniques and use of equipment. Ensures compliance with safety and regulatory requirements. Performs other related duties.</p>